Last Updated -
March 25, 2006
Genetic linkage analysis
is a statistical method that is used to associate functionality of genes
to their location on chromosomes. The main idea is that markers which
are found in vicinity on the chromosome have a tendency to stick together
when passed on to offsprings. Thus, if some disease is often passed
to offsprings along with specific markers, then it can be concluded that
the gene(s) which are responsible for the disease are located close on
the chromosome to these markers.
Superlink is a computer program that performs exact genetic linkage analysis with input-output relationships similar to those in standard genetic linkage programs Linkage, Fastlink v4.1, Tlinkage, Vitesse v2.0, and Genehunter v2.1. Superlink can run larger files than previous programs.
Features of Superlink
Modifications introduced into Version 1.6
Experimental results of Version 1.5 (updated May 11, 2005).
results of Version 1.4 (updated November 24, 2004).
Format of Input Files
Superlink's input format is almost the same as that of Linkage/Fastlink (see Linkage User's Guide) except for Superlink's additional options. The input format for two-loci traits is identical to the one used by Tlinkage. The two additional program options of Superlink require a slightly modified input format which is explained in more detail in Format of Locus file. Some options of Linkage/Fastlink have not been implemented, as detailed in Format of Locus file.
There are two input files. One file describes the loci being analyzed (locus file). The second file holds information regarding the pedigree (pedigree file).
Executables (Version 1.6)
You can also use Superlink without downloading it via a simple web interface Superlink-online which is faster due to the use of thousands of computers worldwide.
For comments and bug reports please send email