version 1.4

Last Updated -  November 24, 2004


        Genetic linkage analysis is a statistical method that is used to associate functionality of genes to their location on chromosomes.  The main idea is that markers which are found in vicinity on the chromosome have a tendency to stick together when passed on to offsprings.  Thus, if some disease is often passed to offsprings along with specific markers, then it can be concluded that the gene(s) which are responsible for the disease are located close on the chromosome to these markers.
        Superlink is a computer program that performs exact genetic linkage analysis with input-output relationships similar to those in  standard genetic linkage programs Linkage, Fastlink v4.1, Tlinkage, Vitesse v2.0, and Genehunter v2.1.  Superlink can run larger files than previous programs.

Features of Superlink

Modifications introduced into Version 1.4

Experimental Results        Experimental results of Version 1.2 (updated March 30, 2003).        Experimental results of Version 1.0 (updated January 2nd, 2002).

Executables (Version 1.4)

Format of Input Files

        Superlink's input format is almost the same as that of Linkage/Fastlink (see Linkage User's Guide) except for Superlink's additional options. The input format for two-loci traits is identical to the one used by Tlinkage. The two additional program options of Superlink require a slightly modified input format which is explained in more detail in Format of Locus file. Some options of Linkage/Fastlink have not been implemented, as detailed in Format of Locus file.

        There are two input files. One file describes the loci being analyzed (locus file).  The second file holds information regarding the pedigree (pedigree file).

Operating Instructions

Previous Versions

Publication References


For comments and bug reports please send email to pedtool.

Written by Ma'ayan Fishelson.