| who |
- Master Scientist at Agilent Laboratories
- Adjunct Professor at the Department of Computer Science, the Technion
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| Research Interests |
Research in my group addresses algorithmic, statistical and other information aspects of molecular measurement in the context of genomics and proteomics. Active and past projects include:
- Statistical analysis of ranked lists
- miRNA and other non-coding RNA
- DNA copy number variation
- Systems biology
- Computational epigenomics
- Analysis of gene expression data
- Combinatorial optimization and assay design for novel measurement technology
A list of selected publications can be found here.
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| Teaching |
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Classes
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Student Projects
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| Students |
Current Students:
- Israel Steinfeld, PhD - Assay design and data analysis in studies combining multiple high throughput measurement technologies.
- Yaara David, MSc - Analysis of time of replication data; Joint with Prof Yonina Eldar, Technion.
- Limor Leibovich, MSc - Regulation Mechanisms of non-coding RNA.
- Roy Navon, MSc - Rank based statistics in analyzing high-throughput genomic data; Joint with Prof Benny Chor, TAU.
- Shay Ben-Elazar, MSc; Joint with Dr Itai Yanai, Technion.
Former Students:
- Eran Eden, MSc 2007. Discovering Motifs in Ranked Lists of DNA Sequences. Thesis
- Doron Lipson, PhD 2007 - Computational Aspects of DNA Copy Number Measurement. Thesis
- Chaya Ben-Zaken Zilberstein, PhD 2006 - Spotting Regulatory Elements by Micro- Arrays.
- Ari Frank, MSc 2002 - Feature selection in gene expression data; Joint with Prof Dan Geiger, Technion.
- Doron Lipson, MSc 2002 - Optimization Problems in Design of Olinucleotides for Hybridization-based Methods; Joint with Prof Uri Sivan, Technion. Thesis
Also acted as consultant for the following:
- Elinor Dehan, MSc 2005 - CGH and expression profiling of NSCLC; Dr Naftali Kaminski, TAU.
- Nurit Gal, MSc 2005 - Gene expression induced by TGF-beta stimulation; Dr Naftali Kaminski, TAU.
- Efrat Manisterski, MSc 2003 - Designing optimally multiplexed SNP genotyping assays; Prof Yonatan Aumann
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| Software |
- GOrilla - a tool for identifying and visualizing enriched GO terms in ranked lists of genes. Developed by Roy Navon, Eran Eden, Israel Steinfeld and Doron Lipson.
- MonoClad- find meaningful partitions using semi-supervised class discovery. Developed by Israel Steinfeld and Roy Navon.
- DRIM - a tool for discovering motifs in a list of ranked DNA sequences. Developed by Eran Eden.
- HaarSeg- a segmentation algorithm for tiling microarrays. Developed by Erez Ben-Yaacov.
- Stepgram - application for aberration calling in aCGH data Developed by Doron Lipson.
- ATRHunter- find approximate tandem repeats in a genomic sequence. Developed by Ydo Wexler.
- GeneSelector - find a small subset of genes for classification of expression data. Developed by Ari Frank.
- ProbeSpec - for mapping the specificity of all candidate probes for a given sequence. Developed by Doron Lipson.
- SimTree - online tool for computing the similarity between RNA secondary structures. Developed by Eran Eden and Izhar Wallach.
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| Group Pictures |
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| Contact Information |
e-mail (Best!!!): zohar_yakhini@agilent.com
Office at the Technion: +972 4 829 4937
Cell-phone: +972 52 4299 728
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